• Biology, Medicine
  • Published in Nature Genetics 1999
  • DOI:10.1038/12696

Mitochondrial DNA genotypes in nuclear transfer-derived cloned sheep

@article{Evans1999MitochondrialDG,
  title={Mitochondrial DNA genotypes in nuclear transfer-derived cloned sheep},
  author={Matthew J Evans and Cagan Gurer and John D. Loike and Ian Wilmut and Angelika E. Schnieke and Eric A. Schon},
  journal={Nature Genetics},
  year={1999},
  volume={23},
  pages={90-93}
}
Eukaryotic cells contain two distinct genomes. One is located in the nucleus (nDNA) and is transmitted in a mendelian fashion, whereas the other is located in mitochondria (mtDNA) and is transmitted by maternal inheritance. Cloning of mammals1,2,3,4,5,6 typically has been achieved via nuclear transfer, in which a donor somatic cell is fused by electoporation with a recipient enucleated oocyte. During this whole-cell electrofusion, nDNA as well as mtDNA ought to be transferred to the oocyte7,8… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 68 CITATIONS, ESTIMATED 45% COVERAGE

Production of healthy cloned mice from bodies frozen at -20 degrees C for 16 years.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2008
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Cellular and Molecular Basis of Mitochondrial Inheritance

  • Advances in Anatomy, Embryology and Cell Biology
  • 2019

FILTER CITATIONS BY YEAR

2000
2019

CITATION STATISTICS

  • 8 Highly Influenced Citations

References

Publications referenced by this paper.
SHOWING 1-10 OF 29 REFERENCES