Mitochondrial DNA deletions are associated with non-B DNA conformations

@inproceedings{Damas2012MitochondrialDD,
  title={Mitochondrial DNA deletions are associated with non-B DNA conformations},
  author={Joana Damas and Joao Carneiro and J. M. Gonçalves and James B Stewart and David C. Samuels and Ant{\'o}nio Amorim and Filipe Pereira},
  booktitle={Nucleic acids research},
  year={2012}
}
Mitochondrial DNA (mtDNA) deletions are a primary cause of mitochondrial disease and are believed to contribute to the aging process and to various neurodegenerative diseases. Despite strong observational and experimental evidence, the molecular basis of the deletion process remains obscure. In this study, we test the hypothesis that the primary cause of mtDNA vulnerability to breakage resides in the formation of non-B DNA conformations, namely hairpin, cruciform and cloverleaf-like elements… CONTINUE READING
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