Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis

Abstract

OBJECTIVE Cerebral atrophy is a correlate of clinical progression in multiple sclerosis (MS). Mitochondria are now established to play a part in the pathogenesis of MS. Uniquely, mitochondria harbor their own mitochondrial DNA (mtDNA), essential for maintaining a healthy central nervous system. We explored mitochondrial respiratory chain activity and mtDNA… (More)
DOI: 10.1002/ana.22109

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