Mitochondrial DNA deletion mutations: a causal role in sarcopenia.

  title={Mitochondrial DNA deletion mutations: a causal role in sarcopenia.},
  author={Debbie McKenzie and Entela A Bua and Susan H. McKiernan and Zhengjin Cao and Judd M. Aiken},
  journal={European journal of biochemistry},
  volume={269 8},
Mitochondrial DNA (mtDNA) deletion mutations accumulate with age in tissues of a variety of species. Although the relatively low calculated abundance of these deletion mutations in whole tissue homogenates led some investigators to suggest that these mutations do not have any physiological impact, their focal and segmental accumulation suggests that they can, and do, accumulate to levels sufficient to affect the metabolism of a tissue. This phenomenon is most clearly demonstrated in skeletal… CONTINUE READING
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