Mitochondrial DNA damage triggers mitochondrial-superoxide generation and apoptosis.

  title={Mitochondrial DNA damage triggers mitochondrial-superoxide generation and apoptosis.},
  author={Craig Ricci and Viktor Pastukh and Josh Leonard and Julio F. Turrens and Glenn Wilson and David Schaffer and Stephen W. Schaffer},
  journal={American journal of physiology. Cell physiology},
  volume={294 2},
Recently, it has become apparent that mitochondrial DNA (mtDNA) damage can rapidly initiate apoptosis independent of mutations, although the mechanism involved remains unclear. To elucidate this mechanism, angiotensin II-mediated apoptosis was studied in cells that were transduced with a lentiviral vector to overexpress the DNA repair enzyme 8-oxoguanine glycosylase or were treated with inhibitors known to block angiotensin II-induced mtDNA damage. Cells exhibiting angiotensin II-induced mtDNA… CONTINUE READING


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