Mitochondrial DNA damage patterns and aging: revising the evidences for humans and mice.

@article{Kazachkova2013MitochondrialDD,
  title={Mitochondrial DNA damage patterns and aging: revising the evidences for humans and mice.},
  author={Nadiya Kazachkova and Amanda Lu{\'i}ze Melo Tavares Ramos and Cristina Maria B. Santos and Manuela Azevedo Correia Lima},
  journal={Aging and disease},
  year={2013},
  volume={4 6},
  pages={337-50}
}
A significant body of work, accumulated over the years, strongly suggests that damage in mitochondrial DNA (mtDNA) contributes to aging in humans. Contradictory results, however, are reported in the literature, with some studies failing to provide support to this hypothesis. With the purpose of further understanding the aging process, several models, among which mouse models, have been frequently used. Although important affinities are recognized between humans and mice, differences on what… CONTINUE READING

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