Mitochondrial DNA damage is involved in apoptosis caused by pro-inflammatory cytokines in human OA chondrocytes.

@article{Kim2010MitochondrialDD,
  title={Mitochondrial DNA damage is involved in apoptosis caused by pro-inflammatory cytokines in human OA chondrocytes.},
  author={Jin Young Kim and M Xu and R Xo and Anca Mateş and Glenn L. Wilson and A. W. Pearsall and Valentina I. Grishko},
  journal={Osteoarthritis and cartilage},
  year={2010},
  volume={18 3},
  pages={424-32}
}
OBJECTIVE Pro-inflammatory cytokines play a pivotal role in cartilage destruction during the progression of osteoarthritis (OA). Additionally, these cytokines are capable to generate reactive oxygen and nitrogen species within chondrocytes. Mitochondrion is a prime target of oxidative damage and an important player in aging and degenerative processes. The purpose of the present study was to investigate whether these cytokines will alter the mitochondrial DNA (mtDNA) integrity and mitochondrial… CONTINUE READING

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