Mitochondrial DNA copy number in peripheral blood cells declines with age and is associated with general health among elderly

@article{MengelFrom2014MitochondrialDC,
  title={Mitochondrial DNA copy number in peripheral blood cells declines with age and is associated with general health among elderly},
  author={Jonas Mengel-From and Mikael Thinggaard and Christine Dalg{\aa}rd and Kirsten Ohm Kyvik and Kaare Christensen and Lene Christiansen},
  journal={Human Genetics},
  year={2014},
  volume={133},
  pages={1149-1159}
}
The role of the mitochondria in disease, general health and aging has drawn much attention over the years. Several attempts have been made to describe how the numbers of mitochondria correlate with age, although with inconclusive results. In this study, the relative quantity of mitochondrial DNA compared to nuclear DNA, i.e. the mitochondrial DNA copy number, was measured by PCR technology and used as a proxy for the content of mitochondria copies. In 1,067 Danish twins and singletons (18–93… CONTINUE READING
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