Mitochondrial DNA copy number and replication in reprogramming and differentiation.

  title={Mitochondrial DNA copy number and replication in reprogramming and differentiation.},
  author={Justin C St John},
  journal={Seminars in cell & developmental biology},
Until recently, it was thought that the role of the mitochondrial genome was confined to encoding key proteins that generate ATP through the process of oxidative phosphorylation in the electron transfer chain. However, with increasing new evidence, it is apparent that the mitochondrial genome has a major role to play in a number of diseases and phenotypes. For example, mitochondrial variants and copy number have been implicated in the processes of fertilisation outcome and development and the… CONTINUE READING
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