Mitochondrial DNA copy number and exposure to polycyclic aromatic hydrocarbons.

  title={Mitochondrial DNA copy number and exposure to polycyclic aromatic hydrocarbons.},
  author={Sofia Pavanello and Laura Dioni and Mirjam Hoxha and Ugo Fedeli and Danuta Mielzynska-Svach and Andrea A. Baccarelli},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  volume={22 10},
BACKGROUND Increased mitochondrial DNA copy number (mtDNAcn) is a biologic response to mtDNA damage and dysfunction, predictive of lung cancer risk. Polycyclic aromatic hydrocarbons (PAHs) are established lung carcinogens and may cause mitochondrial toxicity. Whether PAH exposure and PAH-related nuclear DNA (nDNA) genotoxic effects are linked with increased mtDNAcn has never been evaluated. METHODS We investigated the effect of chronic exposure to PAHs on mtDNAcn in peripheral blood… CONTINUE READING