Mitochondrial DNA copy number, but not haplogroup is associated with keratoconus in Han Chinese population.

Abstract

Oxidative stress may play a role in the pathogenesis of keratoconus (KC). Mitochondrial DNA (mtDNA) is closely related to mitochondrion function, and variations may affect the generation of reactive oxygen species (ROS) and be involved in the pathogenesis of KC. To test whether mtDNA background and copy number confer genetic susceptibility to KC in the Han… (More)
DOI: 10.1016/j.exer.2015.01.016

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