Mitochondrial DNA as a marker of molecular diversity: a reappraisal.

@article{Galtier2009MitochondrialDA,
  title={Mitochondrial DNA as a marker of molecular diversity: a reappraisal.},
  author={Nicolas Galtier and Benoit Nabholz and Sylvain Gl{\'e}min and Gregory D D Hurst},
  journal={Molecular ecology},
  year={2009},
  volume={18 22},
  pages={4541-50}
}
Over the last three decades, mitochondrial DNA has been the most popular marker of molecular diversity, for a combination of technical ease-of-use considerations, and supposed biological and evolutionary properties of clonality, near-neutrality and clock-like nature of its substitution rate. Reviewing recent literature on the subject, we argue that mitochondrial DNA is not always clonal, far from neutrally evolving and certainly not clock-like, questioning its relevance as a witness of recent… CONTINUE READING
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