Mitochondrial DNA as a cancer biomarker.

@article{Jakupciak2005MitochondrialDA,
  title={Mitochondrial DNA as a cancer biomarker.},
  author={John P. Jakupciak and Wendy X. Wang and Maura E Markowitz and Delphine Ally and Michael D. Coble and Sudhir Srivastava and Anirban Maitra and Peter E. Barker and David Sidransky and Catherine D. O'Connell},
  journal={The Journal of molecular diagnostics : JMD},
  year={2005},
  volume={7 2},
  pages={258-67}
}
As part of a national effort to identify biomarkers for the early detection of cancer, we developed a rapid and high-throughput sequencing protocol for the detection of sequence variants in mitochondrial DNA. Here, we describe the development and implementation of this protocol for clinical samples. Heteroplasmic and homoplasmic sequence variants occur in the mitochondrial genome in patient tumors. We identified these changes by sequencing mitochondrial DNA obtained from tumors and blood from… CONTINUE READING

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