Mitochondrial DNA as a Genomic Jigsaw Puzzle

@article{Marande2007MitochondrialDA,
  title={Mitochondrial DNA as a Genomic Jigsaw Puzzle},
  author={William Marande and Gertraud Burger},
  journal={Science},
  year={2007},
  volume={318},
  pages={415 - 415}
}
In mitochondria of the unicellular eukaryote Diplonema, genes are systematically fragmented into small pieces that are encoded on separate chromosomes, transcribed individually, and then concatenated into contiguous messenger RNA molecules 

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References

SHOWING 1-6 OF 6 REFERENCES
Mitochondria of protists.
TLDR
Comparison of mtDNA sequence data has provided insights into the radically diverse trends in mitochondrial genome evolution exhibited by different phylogenetically coherent groupings of eukaryotes, and has allowed us to pinpoint specific protist relatives of the multicellular eUKaryotic lineages. Expand
Unique Mitochondrial Genome Structure in Diplonemids, the Sister Group of Kinetoplastids
TLDR
The mitochondrial genome and the mitochondrial ultrastructure of Diplonema papillatum, a member of the diplonemid flagellates, the sister group of kinetoplastids, are described, which is unique among eukaryotes as a whole. Expand
Complex management: RNA editing in trypanosomes.
TLDR
A picture of highly organized complexes is emerging that shows that the complex that catalyzes the central steps of editing is partitioned into distinct insertion and deletion editing subcomplexes. Expand
Diversity and Evolution of Mitochondrial RNA Editing Systems
TLDR
The derived nature of RNA editing raises intriguing questions about how and why RNA editing systems arise, and how they become fixed as additional, essential steps in genetic information transfer. Expand
Trans‐splicing of pre‐mRNA in plants, animals, and protists
  • L. Bonen
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1993
TLDR
In this review, the phenomenon of pre‐mRNA trans‐splicing has been divided into two categories; the “spliced leader” type, found in protozoans such as trypanosomes and lower invertebrates such as nematodes, results in the addition of a short, capped 5′ noncoding sequence to the mRNA. Expand
Protein phylogenies robustly resolve the deep-level relationships within Euglenozoa.
TLDR
Protein analyses of two nuclear-encoded proteins suggest that bodonids are paraphyletic, with trypanosomatids grouping with 'clade 2' and 'Clade 3' bodonid to the exclusion of 'clades 1' and 2, and that euglenid Euglena gracilis is excluded from this group. Expand