Mitochondrial DNA and human evolution

  title={Mitochondrial DNA and human evolution},
  author={Rebecca Louise Cann and Mark Stoneking and Allan Charles Wilson},
Mitochondrial DNAsfrom 147 people, drawn from five geographic populations have been analysed by restriction mapping. All these mitochondrial DMAs stem from one woman who is postulated to have lived about 200,000 years ago, probably in Africa. All the populations examined except the African population have multiple origins, implying that each area was colonised repeatedly. 

Linkage disequilibrium and recombination in hominid mitochondrial DNA.

The assumption that human mitochondrial DNA is inherited from one parent only and therefore does not recombine is questionable. Linkage disequilibrium in human and chimpanzee mitochondrial DNA

Polymorphism of Human Mitochondrial DNA

This work has shown that the use of direct sequencing of the main noncoding region of mtDNA along with the RFLP analysis provide performance of complex analysis of mt DNA polymorphism in human populations.

Studies of human genetic history using mtDNA variation

Current studies of human mitochondrial DNA have revealed that the dissection of its variation into smaller and younger subhaplogroups is an essential step in the identification of spatial frequency

Human evolution and the mitochondrial genome.

Maternal transmission of mitochondrial DNA in ducks.

The past within us

The recognition of new Y-chromosome markers represents a major leap in the investigation of human genetic diversity and supports the out-of-Africa origins of the authors' species and opens the way to further insights into prehistoric demography and world prehistory.

Human evolution: Sex-specific contributions to genome variation

Modern Humans: Origin and Evolution

Modern humans originated recently in geological time from a diverse African gene pool. Very little if any interbreeding probably occurred with existing archaic human populations outside of Africa



Human mitochondrial DNA types in two Israeli populations--a comparative study at the DNA level.

Variations in human mtDNA restriction endonuclease fragment patterns were investigated in a sample number of 81 Israelis--Jews and Arabs--using total blood cell DNA, finding one of the new types filled a "missing link" originally postulated in a phylogeny of mtDNA human types.

Genetic and fossil evidence for the origin of modern humans.

Genetic data on present human population relationships and data from the Pleistocene fossil hominid record are used to compare two contrasting models for the origin of modern humans.

Nucleotide sequence evidence for rapid genotypic shifts in the bovine mitochondrial DNA D-loop

The nucleotide sequence of all or part of the D-loop region in 14 maternally related Holstein cows is determined to help answer the question of how individual variant mtDNA molecules resulting from mutational events can come to dominate the large intracellular mtDNA population so rapidly.

Dramatic founder effects in Amerindian mitochondrial DNAs.

Southwestern American Indian (Amerindian) mitochondrial DNAs (mtDNAs) were analyzed with restriction endonucleases and found to contain Asian restriction fragment length polymorphisms (RFLPs) but at

Evolutionary tree for apes and humans based on cleavage maps of mitochondrial DNA.

Although this study has given a magnified view of the genetic differences among humans and apes, the possibility of a three-way split among the lineages leading to humans, gorillas, and chimpanzees still deserves serious consideration.

Maternal inheritance of human mitochondrial DNA.

The results of this study demonstrate that human mitochondrial DNA is maternally inherited and represents a convenient way to obtain data on mitochondrial DNA variation in both individuals and populations.

Mitochondrial DNA and two perspectives on evolutionary genetics

This essay reviews comparative studies of animal mitochondrial DNA (mtDNA), with emphasis on findings made and ideas developed at Berkeley. It argues that such studies are bringing together two

Polymorphism in mitochondrial DNA of humans as revealed by restriction endonuclease analysis.

  • W. Brown
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1980
The data indicate that individuals differ from a postulated ancestral mtDNA sequence at 0.18% of their base pairs, and suggest that group-specific patterns of cleavage exist.

Polymorphic sites and the mechanism of evolution in human mitochondrial DNA.

This example, along with that for the mitochondrial rRNA genes and the nuclear genes coding for mitochondrial ribosomal proteins, provides evidence for coevolution between specific nuclear and mitochondrial genes.

Evolutionary relationships of human populations from an analysis of nuclear DNA polymorphisms

It is found that all non-African populations share a limited number of common haplotypes whereas Africans have predominantly a different haplotype not found in other populations.