Mitochondrial DNA and gastrointestinal motor and sensory functions in health and functional gastrointestinal disorders.


Nerve, muscle, and inflammatory cells involved in gastrointestinal (GI) function have high-energy requirements and are affected in mitochondrial disorders. Familial aggregation of irritable bowel syndrome (IBS) frequently involves mothers and their children. Since mitochondrial DNA (mtDNA) is maternally inherited, mtDNA single nucleotide polymorphisms (SNPs… (More)
DOI: 10.1152/ajpgi.90650.2008


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