• DOI:10.1042/CS20040148
Corpus ID: 5747202

Mitochondrial DNA and aging.

@article{Alexeyev2004MitochondrialDA,
  title={Mitochondrial DNA and aging.},
  author={M. Alexeyev and S. Ledoux and G. Wilson},
  journal={Clinical science},
  year={2004},
  volume={107 4},
  pages={
          355-64
        }
}

M. Alexeyev, S. Ledoux, G. Wilson

Published 2004

Biology, Medicine

Clinical science

Among the numerous theories that explain the process of aging, the mitochondrial theory of aging has received the most attention. This theory states that electrons leaking from the ETC (electron transfer chain) reduce molecular oxygen to form O2*- (superoxide anion radicals). O2*-, through both enzymic and non-enzymic reactions, can cause the generation of other ROS (reactive oxygen species). The ensuing state of oxidative stress results in damage to ETC components and mtDNA (mitochondrial DNA… CONTINUE READING

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