Mitochondrial DNA alterations in cancer.

  title={Mitochondrial DNA alterations in cancer.},
  author={William C. Copeland and Joseph T Wachsman and Frank M. Johnson and John S. Penta},
  journal={Cancer investigation},
  volume={20 4},
A number of studies have demonstrated the presence of mitochondrial DNA (mtDNA) mutations in cancer cells. In this article, we review mitochondrial genomic aberrations reported in solid tumors of the breast, colon, stomach, liver, kidney, bladder, head/neck, and lung. The tantalizing association of tumors with mtDNA mutations implicates these mutations in the process of carcinogenesis. Alterations in expression of mtDNA transcripts in a variety of cancer types are also reviewed. In solid tumors… CONTINUE READING