Mitochondrial DNA Sequence Analysis - Validation and Use for Forensic Casework.

@article{Holland1999MitochondrialDS,
  title={Mitochondrial DNA Sequence Analysis - Validation and Use for Forensic Casework.},
  author={Mitchell M. Holland and T. J. Parsons},
  journal={Forensic science review},
  year={1999},
  volume={11 1},
  pages={21-50}
}
With the discovery of the polymerase chain reaction (PCR) in the mid-1980's, the last in a series of critical molecular biology techniques (to include the isolation of DNA from human and non-human biological material, and primary sequence analysis of DNA) had been developed to rapidly analyze minute quantities of mitochondrial DNA (mtDNA). This was especially true for mtDNA isolated from challenged sources, such as ancient or aged skeletal material and hair shafts. One of the beneficiaries of… CONTINUE READING