Mitochondrial DNA Released by Trauma Induces Neutrophil Extracellular Traps

  title={Mitochondrial DNA Released by Trauma Induces Neutrophil Extracellular Traps},
  author={Kiyoshi Itagaki and Elżbieta Kaczmarek and Yen Ting Lee and I. Tien Tang and Burak Isal and Yashar Adibnia and Nicola Sandler and Melissa J. Grimm and Brahm H. Segal and Leo E Otterbein and Carl J. Hauser},
  booktitle={PloS one},
Neutrophil extracellular traps (NETs) are critical for anti-bacterial activity of the innate immune system. We have previously shown that mitochondrial damage-associated molecular patterns (mtDAMPs), including mitochondrial DNA (mtDNA), are released into the circulation after injury. We therefore questioned whether mtDNA is involved in trauma-induced NET formation. Treatment of human polymorphoneutrophils (PMN) with mtDNA induced robust NET formation, though in contrast to phorbol myristate… CONTINUE READING
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