Mitochondrial D310 mutations in the early development of breast cancer

@inproceedings{Xu2012MitochondrialDM,
  title={Mitochondrial D310 mutations in the early development of breast cancer},
  author={Chao Xu and Danh Tran-Thanh and Chao-qun Ma and Klaus May and Jinsei Jung and Jonathan Vecchiarelli and Susan J Done},
  booktitle={British Journal of Cancer},
  year={2012}
}
Background:The role of mitochondrial DNA (mtDNA) mutations in the development of breast cancer is largely unknown. In this study, we investigated the frequency and pattern of mutations in the D310 region, the most commonly mutated region in mtDNA, in a series of breast lesions.Methods:Using capillary electrophoresis, we genotyped the D310 sequence of neoplastic epithelial cells from 23 patients with synchronous ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC), 26 patients… CONTINUE READING

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