Mitochondrial D310 instability in Chinese lung cancer patients.

  title={Mitochondrial D310 instability in Chinese lung cancer patients.},
  author={Xianzhong Chen and Yu Fang and Y H Shi and Jing-hui Cui and L Y Li and Yong-chen Xu and Bin Ling},
  journal={Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis},
  volume={27 2},
To characterize the somatic mutation spectrum of mitochondrial DNA at D310 in Chinese lung cancer patients and evaluate its potential significance in Chinese lung cancer diagnosis, in this study, 237 samples, including lung tumor, adjacent normal tissue and blood samples of 79 lung cancer patients were analyzed. By comparing sequences of D310 between lung cancer tissues, adjacent normal tissue and blood samples, the somatic mutations at D310 were detected in 17.72% (14/79) of Chinese lung… CONTINUE READING
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