Mitochondrial Cristae: Where Beauty Meets Functionality.

  title={Mitochondrial Cristae: Where Beauty Meets Functionality.},
  author={Sara Cogliati and Jos{\'e} Antonio Enr{\'i}quez and Luca Scorrano},
  journal={Trends in biochemical sciences},
  volume={41 3},
Mitochondrial cristae are dynamic bioenergetic compartments whose shape changes under different physiological conditions. Recent discoveries have unveiled the relation between cristae shape and oxidative phosphorylation (OXPHOS) function, suggesting that membrane morphology modulates the organization and function of the OXPHOS system, with a direct impact on cellular metabolism. As a corollary, cristae-shaping proteins have emerged as potential modulators of mitochondrial bioenergetics, a… CONTINUE READING
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