Mitochondrial Complex I decrease is responsible for bioenergetic dysfunction in K-ras transformed cells.

@article{Baracca2010MitochondrialCI,
  title={Mitochondrial Complex I decrease is responsible for bioenergetic dysfunction in K-ras transformed cells.},
  author={Alessandra Baracca and Ferdinando Chiaradonna and Gianluca Sgarbi and Giancarlo Solaini and Lilia Alberghina and Giorgio Lenaz},
  journal={Biochimica et biophysica acta},
  year={2010},
  volume={1797 2},
  pages={314-23}
}
Many cancer cells are characterized by high rate of glycolysis and reduced rate of aerobic respiration, whose mechanism is still elusive. Here we investigate the down-regulation of oxidative phosphorylation (OXPHOS) in K-ras transformed mouse fibroblasts as compared to a control counterpart. Transcriptional analysis showed different expression levels of several OXPHOS nuclear genes in the two cell lines. In particular, during the exponential growth phase most genes encoding proteins of Complex… CONTINUE READING

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