Mitochondrial Complex I Inhibitor Rotenone Inhibits and Redistributes Vesicular Monoamine Transporter 2 via Nitration in Human Dopaminergic SH-SY5Y Cells

@article{Watabe2008MitochondrialCI,
  title={Mitochondrial Complex I Inhibitor Rotenone Inhibits and Redistributes Vesicular Monoamine Transporter 2 via Nitration in Human Dopaminergic SH-SY5Y Cells},
  author={M. Watabe and T. Nakaki},
  journal={Molecular Pharmacology},
  year={2008},
  volume={74},
  pages={933 - 940}
}
  • M. Watabe, T. Nakaki
  • Published 2008
  • Biology, Medicine
  • Molecular Pharmacology
  • Parkinson's disease is a progressive neurodegenerative disorder characterized by selective degeneration of nigrostriatal dopaminergic neurons. Long-term systemic mitochondrial complex I inhibition by rotenone induces selective degeneration of dopaminergic neurons in rats. We have reported dopamine redistribution from vesicles to the cytosol to play a crucial role in selective dopaminergic cell apoptosis. In the present study, we investigated how rotenone causes dopamine redistribution to the… CONTINUE READING
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