Mitochondrial Calcium Uniporter Affects Neutrophil Bactericidal Activity during Staphylococcus aureus Infection

@article{Monteith2021MitochondrialCU,
  title={Mitochondrial Calcium Uniporter Affects Neutrophil Bactericidal Activity during Staphylococcus aureus Infection},
  author={Andrew J Monteith and Jeanette M Miller and William N. Beavers and K. Nichole Maloney and Erin L. Seifert and Gy{\"o}rgy Hajn{\'o}czky and Eric P. Skaar},
  journal={Infection and Immunity},
  year={2021},
  volume={90}
}
Neutrophils simultaneously restrict Staphylococcus aureus dissemination and facilitate bactericidal activity during infection through the formation of neutrophil extracellular traps (NETs). Neutrophils that produce higher levels of mitochondrial superoxide undergo enhanced terminal NET formation (suicidal NETosis) in response to S. aureus; however, mechanisms regulating mitochondrial homeostasis upstream of neutrophil antibacterial processes are not fully resolved. ABSTRACT Neutrophils… 
2 Citations
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