Mitochondrial Ca2+ uniporter and CaMKII in heart

@article{Fieni2014MitochondrialCU,
  title={Mitochondrial Ca2+ uniporter and CaMKII in heart},
  author={Francesca Fieni and Derrick Ethan Johnson and Andy Hudmon and Yuriy Y Kirichok},
  journal={Nature},
  year={2014},
  volume={513},
  pages={E1-E2}
}
Arising from M. A. Joiner et al. 491, 269–273 (2012); doi:10.1038/nature1023410.1038/nature11444The influx of cytosolic Ca2+ into mitochondria is mediated primarily by the mitochondrial calcium uniporter (MCU), a small-conductance, Ca2+-selective channel—MCU modulates intracellular Ca2+ transients and regulates ATP production and cell death. Recently, Joiner et al. reported that MCU is regulated by mitochondrial CaMKII, and this regulation determines stress response in heart. They reported a… CONTINUE READING
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