Mitochondrial Ca2+ sequestration and precipitation revisited.

  title={Mitochondrial Ca2+ sequestration and precipitation revisited.},
  author={Christos Chinopoulos and Vera {\'A}d{\'a}m-Vizi},
  journal={The FEBS journal},
  volume={277 18},
The ability of mitochondria to sequester and retain divalent cations in the form of precipitates consisting of organic and inorganic moieties has been known for decades. Of these cations, Ca(2+) has emerged as a major player in both signal transduction and cell death mechanisms, and, as a consequence, the importance of mitochondria in these processes was soon recognized. Early studies showed considerable effort in identifying the mechanisms of Ca(2+) sequestration, precipitation and release by… CONTINUE READING


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