Mitochondrial Ca2+ Uptake 1 (MICU1) and Mitochondrial Ca2+ Uniporter (MCU) Contribute to Metabolism-Secretion Coupling in Clonal Pancreatic β-Cells*

@inproceedings{Alam2012MitochondrialCU,
  title={Mitochondrial Ca2+ Uptake 1 (MICU1) and Mitochondrial Ca2+ Uniporter (MCU) Contribute to Metabolism-Secretion Coupling in Clonal Pancreatic β-Cells*},
  author={Muhammad Rizwan Alam and Lukas N. Groschner and Warisara Parichatikanond and Liang Kuo and A. I. Bondarenko and Rene Rost and Markus Waldeck-Weiermair and Roland Malli and Wolfgang F. Graier},
  booktitle={The Journal of biological chemistry},
  year={2012}
}
In pancreatic β-cells, uptake of Ca(2+) into mitochondria facilitates metabolism-secretion coupling by activation of various matrix enzymes, thus facilitating ATP generation by oxidative phosphorylation and, in turn, augmenting insulin release. We employed an siRNA-based approach to evaluate the individual contribution of four proteins that were recently described to be engaged in mitochondrial Ca(2+) sequestration in clonal INS-1 832/13 pancreatic β-cells: the mitochondrial Ca(2+) uptake 1… CONTINUE READING
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