Mitochondrial CB1 receptor is involved in ACEA-induced protective effects on neurons and mitochondrial functions

@article{Ma2015MitochondrialCR,
  title={Mitochondrial CB1 receptor is involved in ACEA-induced protective effects on neurons and mitochondrial functions},
  author={L. Ma and Ji Jia and W. Niu and Tao Jiang and Qian Zhai and L. Yang and Fuhai Bai and Q. Wang and Li-ze Xiong},
  journal={Scientific Reports},
  year={2015},
  volume={5}
}
  • L. Ma, Ji Jia, +6 authors Li-ze Xiong
  • Published 2015
  • Biology, Medicine
  • Scientific Reports
  • Mitochondrial dysfunction contributes to cell death after cerebral ischemia/reperfusion (I/R) injury. Cannabinoid CB1 receptor is expressed in neuronal mitochondrial membranes (mtCB1R) and involved in regulating mitochondrial functions under physiological conditions. However, whether mtCB1R affords neuroprotection against I/R injury remains unknown. We used mouse models of cerebral I/R, primary cultured hippocampal neurons exposed to oxygen-glucose deprivation/reoxygenation (OGD/R) and Ca2… CONTINUE READING

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