Mitochondrial CB1 receptor is involved in ACEA-induced protective effects on neurons and mitochondrial functions

@inproceedings{Ma2015MitochondrialCR,
  title={Mitochondrial CB1 receptor is involved in ACEA-induced protective effects on neurons and mitochondrial functions},
  author={Lei Ma and Ji Zeng Jia and Wen Sheng Niu and Tao Jiang and Qian Zhai and Lei Yang and Fuhai Bai and Qiang Wang and Lize Xiong},
  booktitle={Scientific reports},
  year={2015}
}
Mitochondrial dysfunction contributes to cell death after cerebral ischemia/reperfusion (I/R) injury. Cannabinoid CB1 receptor is expressed in neuronal mitochondrial membranes (mtCB1R) and involved in regulating mitochondrial functions under physiological conditions. However, whether mtCB1R affords neuroprotection against I/R injury remains unknown. We used mouse models of cerebral I/R, primary cultured hippocampal neurons exposed to oxygen-glucose deprivation/reoxygenation (OGD/R) and Ca(2… CONTINUE READING
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