Mitochondrial Bol1 and Bol3 function as assembly factors for specific iron-sulfur proteins

  title={Mitochondrial Bol1 and Bol3 function as assembly factors for specific iron-sulfur proteins},
  author={Marta A. Uzarska and Veronica Nasta and Benjamin D Weiler and Farah Spantgar and Simone Ciofi-Baffoni and Maria Rosaria Saviello and Leonardo Gonnelli and Ulrich M{\"u}hlenhoff and Lucia Banci and Roland Lill},
Assembly of mitochondrial iron-sulfur (Fe/S) proteins is a key process of cells, and defects cause many rare diseases. In the first phase of this pathway, ten Fe/S cluster (ISC) assembly components synthesize and insert [2Fe-2S] clusters. The second phase is dedicated to the assembly of [4Fe-4S] proteins, yet this part is poorly understood. Here, we characterize the BOLA family proteins Bol1 and Bol3 as specific mitochondrial ISC assembly factors that facilitate [4Fe-4S] cluster insertion into… CONTINUE READING
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