Mitochondrial Apoptosis Induced by the HIV‐1 Envelope

@article{Castedo2003MitochondrialAI,
  title={Mitochondrial Apoptosis Induced by the HIV‐1 Envelope},
  author={Maria Castedo and Jean-Luc Perfettini and Karine Andr{\'e}au and Thomas Roumier and Mauro Piacentini and Guido Kroemer},
  journal={Annals of the New York Academy of Sciences},
  year={2003},
  volume={1010}
}
Abstract: The envelope glycoprotein complex (Env), encoded by the human immunodeficiency virus (HIV‐1), kills uninfected cells expressing CD4 and/or the chemokine receptor CXCR4 or CCR5, via at least three independent mechanisms. First, the soluble Env product gp120 can induce the apoptotic cell death of lymphocytes, neurons, and myocardiocytes, via interaction with surface receptors. Second, Env present on the surface of HIV‐1 infected cells can transiently interact with cells expressing CD4… 

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