Mitochondrial Abnormality Facilitates Cyst Formation in Autosomal Dominant Polycystic Kidney Disease

  title={Mitochondrial Abnormality Facilitates Cyst Formation in Autosomal Dominant Polycystic Kidney Disease},
  author={Yu Ishimoto and Reiko Inagi and Daisuke Yoshihara and Masanori Kugita and Shizuko Nagao and Akira Shimizu and Norihiko Takeda and Masaki Wake and Kenjiro Honda and Jing Zhou and Masaomi Nangaku},
  booktitle={Molecular and cellular biology},
Autosomal dominant polycystic kidney disease (ADPKD) constitutes the most common inherited kidney disease. Mutations in the PKD1 and PKD2 genes, encoding respective polycystin-1 and polycystin-2 Ca2+ ion channels, results in tubular epithelial cell-derived renal cysts. Recent clinical studies demonstrate oxidative stress as present early in ADPKD. Mitochondria comprise the primary reactive oxygen species source and also their main effector target; however, the pathophysiological role of… CONTINUE READING
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