Mitochondrial ATPase and high-energy phosphates in failing hearts.

  title={Mitochondrial ATPase and high-energy phosphates in failing hearts.},
  author={Jing Liu and Chunlei Wang and Yo Murakami and Guangrong Gong and Yuji Ishibashi and Catherine A. Prody and Ko Ochiai and Robert J. Bache and Catherine Godinot and Jianyi Jay Zhang},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={281 3},
This study examined high-energy phosphates (HEP) and mitochondrial ATPase protein expression in hearts in which myocardial infarction resulted in either compensated left ventricular remodeling (LVR) or congestive heart failure (CHF). The response of HEP (measured via (31)P magnetic resonance spectroscopy) to a modest increase in the cardiac work state produced by dobutamine-dopamine infusion and pacing (if needed) was examined in 17 pigs after left circumflex coronary artery ligation (9 with… CONTINUE READING


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