Mitochondrial ATP synthase subunit 9 is not required for viability of the petite-negative yeast Kluyveromyces lactis

@article{ClarkWalker1997MitochondrialAS,
  title={Mitochondrial ATP synthase subunit 9 is not required for viability of the petite-negative yeast Kluyveromyces lactis},
  author={George Desmond Clark-Walker and Fleur François and Xin Chen and Maria R. Vieira Da Silva and Maurice L. Claisse},
  journal={Current Genetics},
  year={1997},
  volume={31},
  pages={488-493}
}
Specific mutations in nuclear MGI genes encoding the α, β and γ subunits of the mitochondrial inner membrane F1-ATPase complex allow mitochondrial DNA (mtDNA) to be lost from K. lactis. In the absence of a mutation in any of these three nuclear genes, loss of mtDNA is lethal. These results imply that mtDNA encodes a gene that is essential. Likely candidates for such an essential role are the ATP6, 8 and 9 genes coding for proteins of the ATP synthase-F0 component. The present study removes ATP9… CONTINUE READING