Mitochondrial ALDH2 Deficiency as an Oxidative Stress

@article{Ohta2004MitochondrialAD,
  title={Mitochondrial ALDH2 Deficiency as an Oxidative Stress},
  author={Shigeo Ohta and Ikuroh Ohsawa and Kouzin Kamino and Fujiko Ando and Hiroshi Shimokata},
  journal={Annals of the New York Academy of Sciences},
  year={2004},
  volume={1011}
}
Abstract: Mitochondrial aldehyde dehydrogenase 2 (ALDH2) plays a major role in ethanol metabolism. It is involved in acetaldehyde detoxification. A polymorphism of the ALDH2 gene is specific to North‐East Asians. Sensitivity to ethanol is highly associated with this polymorphism (ALDH2*2 allele), which is responsible for a deficiency of ALDH2 activity. We first show that this deficiency influences the risk for late‐onset Alzheimer's disease (LOAD) by a case‐control study in a Japanese… 

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