Mitochondrial Aβ A potential cause of metabolic dysfunction in Alzheimer's disease

  title={Mitochondrial A$\beta$ A potential cause of metabolic dysfunction in Alzheimer's disease},
  author={X. Chen and Shi Du Yan},
  journal={IUBMB Life},
  • X. Chen, S. Yan
  • Published 1 December 2006
  • Biology, Chemistry
  • IUBMB Life
Deficits in mitochondrial function are a characteristic finding in Alzheimer's disease (AD), though the mechanism remains to be clarified. Recent studies revealed that amyloid β peptide (Aβ) gains access into mitochondrial matrix, which was much more pronounced in both AD brain and transgenic mutant APP mice than in normal controls. Aβ progressively accumulates in mitochondria and mediates mitochondrial toxicity. Interaction of mitochondrial Aβ with mitochondrial enzymes such as amyloid… 
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