Mitochondrial Aβ A potential cause of metabolic dysfunction in Alzheimer's disease
@article{Chen2006MitochondrialAA, title={Mitochondrial A$\beta$ A potential cause of metabolic dysfunction in Alzheimer's disease}, author={X. Chen and Shi Du Yan}, journal={IUBMB Life}, year={2006}, volume={58} }
Deficits in mitochondrial function are a characteristic finding in Alzheimer's disease (AD), though the mechanism remains to be clarified. Recent studies revealed that amyloid β peptide (Aβ) gains access into mitochondrial matrix, which was much more pronounced in both AD brain and transgenic mutant APP mice than in normal controls. Aβ progressively accumulates in mitochondria and mediates mitochondrial toxicity. Interaction of mitochondrial Aβ with mitochondrial enzymes such as amyloid…
86 Citations
Pathogenic role of mitochondrial amyloid-β peptide
- Biology, Chemistry
- 2007
It is hypothesized that Aβ-induced and mitochondria-dependent cytotoxic pathways might play an important role in AD pathogenesis and could be a potential therapeutic target.
Role of mitochondrial amyloid-beta in Alzheimer's disease.
- BiologyJournal of Alzheimer's disease : JAD
- 2010
Recent studies addressing the following key questions provide new insights into mechanisms of mitochondrial stress related to the pathogenesis of AD and information necessary for developing therapeutic strategy for AD.
Alzheimer's Proteins, Oxidative Stress, and Mitochondrial Dysfunction Interplay in a Neuronal Model of Alzheimer's Disease
- BiologyInternational journal of Alzheimer's disease
- 2010
The interplay between beta-amyloid peptide, Tau fragments, oxidative stress, and mitochondria in the neuronal model of cerebellar granule neurons (CGNs) in which the molecular events reminiscent of AD are activated could be helpful to manage the progression of apoptosis in neurodegeneration.
Dysfunction of mitochondria: Implications for Alzheimer's disease.
- BiologyInternational review of neurobiology
- 2019
Role of GTPases in the Regulation of Mitochondrial Dynamics in Alzheimer’s Disease and CNS-Related Disorders
- BiologyMolecular Neurobiology
- 2018
An analysis of the correlation between mitochondria, Alzheimer's disease, and other central nervous system (CNS)-related disorders like the Parkinson’s disease and the autism spectrum disorder is under discussion.
Cyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model
- BiologyNeurobiology of Aging
- 2011
β-Amyloid and the Pathomechanisms of Alzheimer’s Disease: A Comprehensive View
- BiologyMolecules
- 2017
Recognition of the above mentioned complex pathogenesis pathway resulted in novel drug targets in AD research.
Amyloid-Binding Alcohol Dehydrogenase (ABAD) Inhibitors for the Treatment of Alzheimer's Disease.
- Biology, ChemistryJournal of medicinal chemistry
- 2019
The chemistry and pharmacology of reported ABAD inhibitors are reviewed to highlight the importance of the interaction between Aβ and amyloid-binding alcohol dehydrogenase in Alzheimer's disease.
Interaction between NH2-tau fragment and Aβ in Alzheimer's disease mitochondria contributes to the synaptic deterioration
- Biology, ChemistryNeurobiology of Aging
- 2012