Mitochondrial ('mild') uncoupling and ROS production: physiologically relevant or not?

@article{Shabalina2011MitochondrialU,
  title={Mitochondrial ('mild') uncoupling and ROS production: physiologically relevant or not?},
  author={Irina G Shabalina and Jan Nedergaard},
  journal={Biochemical Society transactions},
  year={2011},
  volume={39 5},
  pages={1305-9}
}
During the last decade, the possibility that 'mild' uncoupling could be protective against oxidative damage by diminishing ROS (reactive oxygen species) production has attracted much interest. In the present paper, we briefly examine the evidence for this possibility. It is only ROS production from succinate under reverse electron-flow conditions that is sensitive to membrane potential fluctuations, and so only this type of ROS production could be affected; however, the conditions under which… CONTINUE READING