Mitochondria transfection by oligonucleotides containing a signal peptide and vectorized by cationic liposomes.

@article{Gromel2001MitochondriaTB,
  title={Mitochondria transfection by oligonucleotides containing a signal peptide and vectorized by cationic liposomes.},
  author={Vanna G{\'e}romel and An Cao and Dominique Briane and Janny Vassy and Agn{\'e}s Rotig and Pierre Rustin and Robert Coudert and Jean Paul Rigaut and Arnold Munnich and Eliane Taillandier},
  journal={Antisense & nucleic acid drug development},
  year={2001},
  volume={11 3},
  pages={175-80}
}
The progress of research in gene therapy allows hope for treatment of mitochondrial genetic disorders provided that efficient methods for gene transfer into mitochondria can be found. In this work, we have used an oligonucleotide coupled covalently to a mitochondria-targeted peptide at one end and a cationic liposome prepared from trimethyl aminoethane carbamoyl cholesterol iodide (TMAEC-Chol) to carry it in living cells. With a fluorescent probe to label the oligonucleotide at the other end… CONTINUE READING