Mitochondria-targeting "Nanoheater" for enhanced photothermal/chemo-therapy.

  title={Mitochondria-targeting "Nanoheater" for enhanced photothermal/chemo-therapy.},
  author={Si Chen and Qi Lei and Wen-Xiu Qiu and Li-Han Liu and Di-Wei Zheng and Jin-Xuan Fan and Lei Xin Rong and Yun-xia Sun and Xianzheng Zhang},
In this work, mitochondria-targeting gold nanostar (AuNS) and anticarcinogen DOX were co-encapsulated in hyaluronic acid (HA) protective shell for tumor-targeting synergistic photothermal/chemo-therapy. Cationic peptide R8 and mitochondria-targeting pro-apoptotic peptide TPP-KLA were co-decorated on AuNS to form AuNS-pep via Au-S bonds. Then, electronegative HA was further coated on the surface via electrostatic interaction for cancer cell targeting. During the coating process, DOX was also… CONTINUE READING
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