Mitochondria-targeted peptide SS-31 attenuates renal injury via an antioxidant effect in diabetic nephropathy.

@article{Hou2016MitochondriatargetedPS,
  title={Mitochondria-targeted peptide SS-31 attenuates renal injury via an antioxidant effect in diabetic nephropathy.},
  author={Yanjuan Hou and Shuangcheng Li and Ming Wu and Jinying Wei and Yunzhuo Ren and Chunyang Du and Haijiang Wu and Caili Han and Huijun Duan and Yonghong Shi},
  journal={American journal of physiology. Renal physiology},
  year={2016},
  volume={310 6},
  pages={F547-59}
}
Oxidative stress is implicated in the pathogenesis of diabetic kidney injury. SS-31 is a mitochondria-targeted tetrapeptide that can scavenge reactive oxygen species (ROS). Here, we investigated the effect and molecular mechanism of mitochondria-targeted antioxidant peptide SS-31 on injuries in diabetic kidneys and mouse mesangial cells (MMCs) exposed to high-glucose (HG) ambience. CD-1 mice underwent uninephrectomy and streptozotocin treatment prior to receiving daily intraperitoneal injection… CONTINUE READING
14 Citations
55 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 55 references

Similar Papers

Loading similar papers…