Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons.

@article{Manczak2010MitochondriatargetedAP,
  title={Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons.},
  author={Maria Manczak and Peizhong Mao and Marcus J. Calkins and Anda Cornea and A. Pavankumar Reddy and Michael P Murphy and Hazel H. Szeto and Byung Soon Park and Poovendhree. Reddy},
  journal={Journal of Alzheimer's disease : JAD},
  year={2010},
  volume={20 Suppl 2},
  pages={
          S609-31
        }
}
The purpose of our study was to investigate the effects of the mitochondria-targeted antioxidants, MitoQ and SS31, and the anti-aging agent resveratrol on neurons from a mouse model (Tg2576 line) of Alzheimer's disease (AD) and on mouse neuroblastoma (N2a) cells incubated with the amyloid-beta (Abeta) peptide. Using electron and confocal microscopy, gene expression analysis, and biochemical methods, we studied mitochondrial structure and function and neurite outgrowth in N2a cells treated with… CONTINUE READING

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