Mitochondria superoxide dismutase mimetic inhibits peroxide-induced oxidative damage and apoptosis: role of mitochondrial superoxide.

@article{Dhanasekaran2005MitochondriaSD,
  title={Mitochondria superoxide dismutase mimetic inhibits peroxide-induced oxidative damage and apoptosis: role of mitochondrial superoxide.},
  author={Anuradha Dhanasekaran and Srigiridhar Kotamraju and Chandran Karunakaran and Shasi V Kalivendi and Simmy Thomas and Joy Joseph and Balaraman Kalyanaraman},
  journal={Free radical biology & medicine},
  year={2005},
  volume={39 5},
  pages={567-83}
}
The purpose of this study was to test the hypothesis whether Mito-carboxy proxyl (Mito-CP), a mitochondria-targeted nitroxide, inhibits peroxide-induced oxidative stress and apoptosis in bovine aortic endothelial cells (BAEC). Glucose/glucose oxidase (Glu/GO)-induced oxidative stress was monitored by dichlorodihydrofluorescein oxidation catalyzed by intracellular H(2)O(2) and transferrin receptor-mediated iron transported into cells. Pretreatment of BAECs with Mito-CP significantly diminished H… CONTINUE READING

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