Mitochondria-produced superoxide mediates angiotensin II-induced inhibition of neuronal potassium current.

@article{Yin2010MitochondriaproducedSM,
  title={Mitochondria-produced superoxide mediates angiotensin II-induced inhibition of neuronal potassium current.},
  author={Jing-Xiang Yin and Rui-fang Yang and Shumin Li and Alex O Renshaw and Yulong Li and Harold D Schultz and Matthew C Zimmerman},
  journal={American journal of physiology. Cell physiology},
  year={2010},
  volume={298 4},
  pages={C857-65}
}
Reactive oxygen species (ROS), particularly superoxide (O(2)(.-)), have been identified as key signaling intermediates in ANG II-induced neuronal activation and sympathoexcitation associated with cardiovascular diseases, such as hypertension and heart failure. Studies of the central nervous system have identified NADPH oxidase as a primary source of O(2)(.-) in ANG II-stimulated neurons; however, additional sources of O(2)(.-), including mitochondria, have been mostly overlooked. Here, we… CONTINUE READING