Mitochondria of retinal Müller (glial) cells: the effects of aging and of application of free radical scavengers.

@article{Paasche2000MitochondriaOR,
  title={Mitochondria of retinal M{\"u}ller (glial) cells: the effects of aging and of application of free radical scavengers.},
  author={G Paasche and Ulrich G{\"a}rtner and Angela Germer and J. Grosche and Andreas Reichenbach},
  journal={Ophthalmic research},
  year={2000},
  volume={32 5},
  pages={229-36}
}
Age-related changes of mitochondria were studied in Müller (retinal glial) cells from guinea pigs fed with or without externally applied Ginkgo biloba extract EGb 761, an established radical scavenger. When Müller cell mitochondria from aged animals were compared with those from young adults, they displayed (1) a diminished number of well-defined cristae at the ultrastructural level, (2) a reduced membrane potential, as revealed by fluorimetry using the voltage-sensitive dye tetramethyl… CONTINUE READING

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