Mitochondria-mediated apoptosis in human breast carcinoma MCF-7 cells induced by a novel selenadiazole derivative.

@article{Chen2008MitochondriamediatedAI,
  title={Mitochondria-mediated apoptosis in human breast carcinoma MCF-7 cells induced by a novel selenadiazole derivative.},
  author={Tianfeng Chen and Wenjie Zheng and Y. B. Wong and Fang Yang},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={2008},
  volume={62 2},
  pages={77-84}
}
The role of organoselenium compounds as potent cancer chemopreventive and chemotherapeutic agents has been supported by epidemiological, preclinical and clinical studies. In this study, a novel selenadiazole derivative, 1,2,5-selenadiazolo-[3,4-d]pyrimidine-5,7-(4H,6H)-dione (SPO), is identified as a potent antiproliferative agent against human breast adrenocarcinoma MCF-7 cells, human hepatoma HepG2 cells and human melanoma A375 cells. Induction of apoptosis in MCF-7 and A375 cells by SPO was… CONTINUE READING

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