Mitochondria in the programmed death phenomena; a principle of biology: "it is better to die than to be wrong".

@article{Skulachev2000MitochondriaIT,
  title={Mitochondria in the programmed death phenomena; a principle of biology: "it is better to die than to be wrong".},
  author={Vladimir P. Skulachev},
  journal={IUBMB life},
  year={2000},
  volume={49 5},
  pages={
          365-73
        }
}
The very fact that mitochondria participate in amplification of the cell suicide signals has stimulated interest in the mechanism of this and related phenomena. It seems probable that mitochondria possess an autonomic system that allows them to commit suicide. This mitoptosis is mediated by reactive oxygen species (ROS), causing opening of the permeability transition pores (PTP) in the inner mitochondrial membrane. Mitoptosis can purify the mitochondrial population in a cell from the ROS… CONTINUE READING

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