Mitochondria in cell death.

  title={Mitochondria in cell death.},
  author={Melissa J Parsons and Douglas R Green},
  journal={Essays in biochemistry},
Apoptosis can be thought of as a signalling cascade that results in the death of the cell. Properly executed apoptosis is critically important for both development and homoeostasis of most animals. Accordingly, defects in apoptosis can contribute to the development of autoimmune disorders, neurological diseases and cancer. Broadly speaking, there are two main pathways by which a cell can engage apoptosis: the extrinsic apoptotic pathway and the intrinsic apoptotic pathway. At the centre of the… CONTINUE READING