Mitochondria in Ovarian Aging and Reproductive Longevity

@article{Chiang2020MitochondriaIO,
  title={Mitochondria in Ovarian Aging and Reproductive Longevity},
  author={Jasmine L. Chiang and Pallavi Shukla and Kelly Pagidas and Noha S. Ahmed and Srinivasu Karri and Deidre D. Gunn and William W. Hurd and Keshav K. Singh},
  journal={Ageing Research Reviews},
  year={2020},
  volume={63}
}
Mitochondrial dysfunction is one of the hallmarks of aging. Consistently mitochondrial DNA (mtDNA) copy number and function decline with age in various tissues. There is increasing evidence to support that mitochondrial dysfunction drives ovarian aging. A decreased mtDNA copy number is also reported during ovarian aging. However, the mitochondrial mechanisms contributing to ovarian aging and infertility are not fully understood. Additionally, investigations into mitochondrial therapies to… Expand
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