Mitochondria in Ovarian Aging and Reproductive Longevity

  title={Mitochondria in Ovarian Aging and Reproductive Longevity},
  author={Jasmine L. Chiang and Pallavi Shukla and Kelly Pagidas and Noha S. Ahmed and Srinivasu Karri and Deidre D. Gunn and William W. Hurd and Keshav K. Singh},
  journal={Ageing Research Reviews},

Qualitative and Quantitative Ovarian and Peripheral Blood Mitochondrial DNA (mtDNA) Alterations: Mechanisms and Implications for Female Fertility

The present review aims to investigate the evidence about the effect of qualitative and quantitative mtDNA alterations on female fertility, paying particular attention to those with a pathophysiology characterized by a relevant role of oxidative stress.

Potential of Mitochondrial Genome Editing for Human Fertility Health

The features of mitochondria and their unique genome are summarized, emphasizing their inheritance patterns; the role of mtDNA in gametogenesis and fertilization is illustrated; and potential therapies based on MGE as well as the outlook in this field are discussed.

The Mitochondrial Landscape of Ovarian Cancer: Emerging insights.

An overview of role of mitochondrial genetics in influencing OC development is presented and the contribution of mitochondrial proteome in OC development, progression and therapy is discussed.

Aging conundrum: A perspective for ovarian aging

The hallmarks of aging are discussed and the potential role of stem cells and cryopreservation of embryos, oocytes, or ovarian tissue in the delay of ovarian aging is elaborated.

The Role of Mitochondria in Human Fertility and Early Embryo Development: What Can We Learn for Clinical Application of Assessing and Improving Mitochondrial DNA?

The role of mitochondria and mitochondrial DNA in human reproduction is summarized and an insight into the utility of their clinical use is given.

Anti-Müllerian hormone and ovarian aging

  • C. ErelI. B. Ozcivit
  • Biology
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • 2021
The significance of AMH in female reproductive physiology has not yet been fully elucidated and some statistical models which include single or serial measurements of serum AMH level as a variable, have been proposed to predict reliably the time of menopause.

The role of oxidative stress in ovarian aging: a review

A rationale for antioxidant therapy to improve ovarian aging is provided, which suggests that aging, smoking, high-sugar diets, pressure, superovulation, chemotherapeutic agents and industrial pollutants can be factors that accelerate ovarian aging by exacerbating OS status.

Mitochondrial Dysfunction in Chronic Respiratory Diseases: Implications for the Pathogenesis and Potential Therapeutics

This review provides a comprehensive and updated overview of the impact of mitochondrial dysfunction on cellular processes involved in the development of chronic respiratory diseases and provides potential therapeutic approaches for these diseases by targeting dysfunctional mitochondria.

Searching for female reproductive aging and longevity biomarkers

The importance of determining the female biological age is positable and potential research directions in this area are highlighted, including latest advances in the search for potential genetic markers of reproductive aging.

Mitochondria-related changes and metabolic dysfunction in low prognosis patients under the POSEIDON classification.

Mitochondrial abnormality is closely linked to the low prognostic outcome in IVF patients, and supplementing the functional mitochondrial content or improving mitochondrial function by autologous mitochondrial transfer or mitochondrial-related regulating drugs may help improve the clinical outcomes in patients with a low prognosis.



Reproductive aging is associated with decreased mitochondrial abundance and altered structure in murine oocytes

The data support mitochondrial organelle loss and dysfunction in oocyte as a potential etiology for reproductive senescence and aging is associated with a significant decrease in number of mitochondria in oocytes.

Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging

It is concluded that impaired mitochondrial performance created by suboptimal CoQ10 availability can drive age‐associated oocyte deficits causing infertility.

Mitochondrial dysfunction and ovarian aging

Mitochondria are double‐membrane‐bound organelles that are responsible for the generation of most of the cell's energy and have been implicated in cellular senescence in general and ovarian aging in particular.

Somatic mitochondrial DNA mutations in mammalian aging.

  • N. Larsson
  • Biology
    Annual review of biochemistry
  • 2010
Emerging data instead suggest that the inherent error rate of mitochondrial DNA (mtDNA) polymerase gamma (Pol gamma) may be responsible for the majority of somatic mtDNA mutations.

Oocyte mitochondria: role on fertility and disease transmission

The role of mitochondria on oocyte developmental potential and recent evidence supporting a purifying filter against deleterious mtDNA mutations in oocytes are discussed.

Ovarian ageing: the role of mitochondria in oocytes and follicles.

A fuller understanding of the involvement of mitochondria in cases of infertility linked to ovarian ageing would contribute to a better management of the disorder in the future.

Blood Cell Mitochondrial DNA Content and Premature Ovarian Aging

Blood cell mtDNA depletion is a frequent finding among women with premature ovarian aging, suggesting that a still undetermined but generalized mitochondrial defect may frequently predispose to POI which could then be considered a form of anticipated aging in which the ovarian defect may represent the first manifestation.

Low oocyte mitochondrial DNA content in ovarian insufficiency.

The results suggest that low mtDNA content is associated with the impaired oocyte quality observed in ovarian insufficiency.