Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?

@inproceedings{Korolchuk2017MitochondriaIC,
  title={Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?},
  author={Viktor I. Korolchuk and Satomi Miwa and Bernadette Carroll and Thomas von Zglinicki},
  booktitle={EBioMedicine},
  year={2017}
}
Cell senescence is increasingly recognized as a major contributor to the loss of health and fitness associated with aging. Senescent cells accumulate dysfunctional mitochondria; oxidative phosphorylation efficiency is decreased and reactive oxygen species production is increased. In this review we will discuss how the turnover of mitochondria (a term referred to as mitophagy) is perturbed in senescence contributing to mitochondrial accumulation and Senescence-Associated Mitochondrial… CONTINUE READING
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